ONYECHI, SAMUEL ONYEKA

Research Pharmacist & Drug Discovery Scientist
Lagos, NG.

About

Highly analytical and results-driven Research Pharmacist and Drug Discovery Scientist with a Bachelor of Pharmacy, specializing in computer-aided drug design, molecular docking, and antimalarial efficacy studies. Proven ability to leverage advanced research methodologies and pharmaceutical expertise to identify and evaluate novel drug candidates, optimize patient therapy, and contribute significantly to public health initiatives. Eager to apply comprehensive skills in drug discovery, pharmaceutical care, and research data analysis to drive innovation and achieve impactful outcomes in a challenging role.

Work

Kaduna State Drug Supply Management Agency
|

National Youth Service Corps Pharmacist

Kaduna State, Kaduna State, Nigeria

Summary

Led pharmaceutical supply chain operations, ensuring accurate drug requisition, timely distribution, and adherence to regulatory standards for multiple healthcare facilities.

Highlights

Reviewed and verified drug requisitions from multiple healthcare facilities, ensuring 100% accuracy and compliance with pharmaceutical standards.

Collaborated with supply chain and logistics teams to facilitate the timely distribution of essential medicines, improving access for health facilities.

Managed public sector pharmaceutical supply chain and drug distribution systems, gaining hands-on experience in complex operational workflows.

Demonstrated meticulous attention to detail and ethical handling of medicines, ensuring strict adherence to pharmaceutical regulations and patient safety.

Alex Ekwueme Federal University Teaching Hospital
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Intern Pharmacist

Ebonyi State, Ebonyi State, Nigeria

Summary

Provided comprehensive pharmaceutical care, including medication dispensing, patient counseling, and therapy optimization, while collaborating with interdisciplinary healthcare teams.

Highlights

Dispensed medications to patients, providing detailed counseling on dosage, administration, and potential adverse effects to enhance patient adherence and outcomes.

Collaborated with healthcare professionals to assess drug interactions and optimize patient therapy, contributing to improved treatment plans and safety.

Monitored patient drug charts meticulously, ensuring accurate administration instructions and adherence to prescribed regimens.

Drug Discovery and Research Group, University of Uyo, Nigeria
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Research Assistant (Professor Eseyin's Lab)

Uyo, Akwa Ibom State, Nigeria

Summary

Spearheaded drug discovery initiatives, utilizing computational and in vivo models to identify, screen, and evaluate novel drug candidates for malaria and diabetes.

Highlights

Designed 60 natural product analogues using Computer-Aided Drug Design software and conducted molecular docking studies to assess their potential as antimalarial drug candidates.

Performed structure-based virtual screening of over 5,000 ligands against diabetes and malaria target proteins, significantly contributing to early-stage drug discovery.

Evaluated the antimalarial efficacy of a lead ligand, Sirolimus, through molecular docking and in vivo mouse models for drug repurposing, demonstrating practical application of computational findings.

Investigated pharmacokinetic interactions between Sirolimus and Artemether in mice, providing critical data for combination therapy development.

Participated in workshops to instruct students and researchers on computer-aided drug design software (AutoDock, AutoDock Vina, PyRx, Discovery Studio Visualizer, ChemSketch, Open Babel), enhancing institutional research capabilities.

Analyzed complex research data using Microsoft Excel and SPSS, ensuring robust statistical validation of experimental results.

Department of Pharmacognosy & Natural Medicine, University of Uyo, Nigeria
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Undergraduate Research Assistant (Pharm Imo's Lab)

Uyo, Akwa Ibom State, Nigeria

Summary

Conducted comprehensive phytochemical research, including extraction, screening, and antioxidant potential assessment of medicinal plants for drug discovery.

Highlights

Extracted secondary metabolites from various medicinal plants for drug discovery studies, contributing to natural product research.

Conducted thorough phytochemical screening on crude plant extracts, identifying key compounds with therapeutic potential.

Assessed the in vitro antioxidant potential of *Lonchocarpus griseofianus* ethanolic leaf extract using the DPPH model, contributing to understanding its pharmacological properties.

Model Secondary School
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Biology Tutor

Olo, Enugu State, Nigeria

Summary

Delivered engaging biology courses, developed tailored lesson plans, and evaluated student progress to enhance learning outcomes for senior high school students.

Highlights

Delivered comprehensive biology courses following WAEC/NECO syllabuses, improving academic performance for senior high school students (SS1-SS3).

Evaluated student development through tests and assignments, providing constructive criticism that led to measurable improvement in understanding.

Developed customized lesson plans and teaching aids to accommodate diverse learning styles and academic abilities, fostering an inclusive learning environment.

Education

University of Uyo
Uyo, Akwa Ibom State, Nigeria

Bachelor of Pharmacy

Pharmacy

Courses

Thesis: Repurposing Sirolimus as a Single and Combination Therapy for Malaria.

Awards

Award of Service

Awarded By

Pharmaceutical Association of Nigerian Students - National Secretariat

Recognized for dedicated service and contributions to the Pharmaceutical Association of Nigerian Students.

Publications

Repurposing sirolimus as a single and combination therapy for malaria: in silico, in vivo, and pharmacokinetic studies.

Published by

The Journal of Parasitic Diseases

Summary

Research on repurposing sirolimus for malaria therapy through in silico, in vivo, and pharmacokinetic studies.

Drug Repurposing for malaria therapy: An in silico study [Data set].

Published by

Zenodo

Summary

In silico study and dataset on drug repurposing for malaria therapy.

Binding affinities of chalcones, flavonols, sterols, sapogenins, and carbazoles downloaded from PubChem on antimalaria targets [Data set].

Published by

Zenodo

Summary

Dataset on binding affinities of various compounds from PubChem against antimalaria targets.

Molecular Docking and Antimalarial Evaluation of Natural Phenolics and Their Derivatives on Plasmodium falciparum Lactate Dehydrogenase as Schizonticidal Drug Candidates.

Published by

Nigerian Journal of Pharmaceutical and Applied Science Research

Summary

Molecular docking and antimalarial evaluation of natural phenolics against *Plasmodium falciparum* lactate dehydrogenase.

Languages

English

Certificates

Publishing in High-Impact Journal- Tips for Chemists

Issued By

Department of Chemistry, Federal University Otuoke

Data Analytics

Issued By

Axia Africa

Disease Modelling and Target Discovery

Issued By

Insilico Medicine School

Skills

Drug Discovery & Development

Structure-based drug design, Computer-Aided Drug Design, Organic Synthesis, Protein-Ligand Interaction, Molecular Docking, Virtual Screening, Drug Repurposing, Antimalarial Efficacy, Pharmacokinetic Studies, Natural Product Analogues, Lead Ligand Identification.

Research & Analysis

In Silico Studies, In Vivo Models (mouse), Phytochemical Screening, Antioxidant Assays (DPPH), Research Data Analysis, Microsoft Excel, SPSS, Scientific Publication, Experimental Design.

Pharmaceutical Care

Medication Dispensing, Patient Counseling, Drug Interaction Assessment, Patient Therapy Optimization, Drug Chart Monitoring, Pharmaceutical Regulations, Ethical Handling of Medicines.

Supply Chain & Logistics

Drug Requisition Review, Supply Chain Management, Logistics Coordination, Essential Medicine Distribution, Public Sector Pharmaceutical Management.

Teaching & Education

Curriculum Development (WAEC/NECO), Lesson Planning, Student Evaluation, Teaching Aids, Instructional Design, Workshop Facilitation (Computer-Aided Drug Design Software).

Software & Tools

AutoDock, AutoDock Vina, PyRx, Discovery Studio Visualizer, ChemSketch, Open Babel, Microsoft Excel, SPSS.

References

Professor Olorunfemi Eseyin A.

Group Leader, Drug Discovery and Research Group. University of Uyo, Uyo, Nigeria. olorunfemieseyin@uniuyo.edu.ng +2348065161478 Relationship: Mentor/Supervisor.